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Check Closely (one)pentobarbital will decrease the extent or impact of osilodrostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital decreases levels of panobinostat by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Solid CYP3A4 inducers can cut down panobinostat concentrations by ~70% and bring abou